Human Annexin A11 (ANXA11) Protein
234€ (10 µg)
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935106861
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name
Human Annexin A11 (ANXA11) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168206
tested applications
WB, SDS-PAGE
Description
Annexin A11 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Annexin A11 (ANXA11) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 58.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Asp505 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ANXA11,ANX11,Annexin XI |
| Background | Protein ANXA11 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ANXA11 is a multifunctional protein involved in calcium signaling, RNA transport, and cell cycle regulation. It plays an important role in nuclear-cytoplasmic transport by binding RNA and contributing to the assembly of RNA granules. ANXA11 is also critical for cytokinesis, ensuring proper cell division by localizing to the midbody during the final stages of mitosis. Mutations in ANXA11 have been linked to amyotrophic lateral sclerosis (ALS), where defects in RNA transport and protein aggregation contribute to neurodegeneration. Dysregulation of ANXA11 has also been implicated in autoimmune diseases and cancer progression. Its diverse roles in RNA metabolism, calcium signaling, and cytokinesis make ANXA11 essential for cellular homeostasis and division.
