Human Ankyrin 1, Erythrocytic (ANK1) Protein

Este producto es parte de ANK - Ankyrin
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Ankyrin 1, Erythrocytic (ANK1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168126
tested applications
WB, SDS-PAGE

Description

Ankyrin 1, Erythrocytic Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Ankyrin 1, Erythrocytic (ANK1)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 40.5 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Leu32-Leu369
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P16157
Alias
Ankyrin-R,ANK-1
Background
Protein ANK1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ANK1 is a member of the ankyrin family of proteins, which function as cytoskeletal adaptor proteins that link the plasma membrane to the underlying cytoskeleton. ANK1 is primarily expressed in erythrocytes (red blood cells), where it plays a critical role in maintaining the structural integrity and elasticity of the red blood cell membrane by anchoring key membrane proteins such as band 3 and spectrin to the cytoskeleton. Mutations in ANK1 are associated with hereditary spherocytosis, a genetic disorder characterized by red blood cell membrane instability, leading to hemolysis, anemia, and spherical-shaped erythrocytes. ANK1 is also expressed in skeletal muscle and other tissues, where it contributes to cellular organization and membrane stability. Beyond its structural roles, ANK1 is implicated in cellular signaling and ion transport regulation. Dysregulation of ANK1 has been linked to erythrocyte disorders, impaired oxygen delivery, and cellular stress responses, highlighting its critical role in membrane-cytoskeletal interactions.

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