Human Ankyrin 1, Erythrocytic (ANK1) Protein

Este producto es parte de ANK - Ankyrin
Human Ankyrin 1, Erythrocytic (ANK1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ANK1

proveedor

Abbexa

reference

abx168126

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Ankyrin 1, Erythrocytic Protein is a recombinant Human protein expressed in E. coli.


Background

ANK1 is a member of the ankyrin family of proteins, which function as cytoskeletal adaptor proteins that link the plasma membrane to the underlying cytoskeleton. ANK1 is primarily expressed in erythrocytes (red blood cells), where it plays a critical role in maintaining the structural integrity and elasticity of the red blood cell membrane by anchoring key membrane proteins such as band 3 and spectrin to the cytoskeleton. Mutations in ANK1 are associated with hereditary spherocytosis, a genetic disorder characterized by red blood cell membrane instability, leading to hemolysis, anemia, and spherical-shaped erythrocytes. ANK1 is also expressed in skeletal muscle and other tissues, where it contributes to cellular organization and membrane stability. Beyond its structural roles, ANK1 is implicated in cellular signaling and ion transport regulation. Dysregulation of ANK1 has been linked to erythrocyte disorders, impaired oxygen delivery, and cellular stress responses, highlighting its critical role in membrane-cytoskeletal interactions.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Ankyrin 1, Erythrocytic (ANK1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 40.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu32-Leu369 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ANK1


dry ice

No


availability

Shipped within 5-7 working days.


alias

Ankyrin-R,ANK-1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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