Human Anaphase-Promoting Complex Subunit CDC26 / APC12 (CDC26) ELISA Kit
715€ (96 tests)
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name
Human Anaphase-Promoting Complex Subunit CDC26 / APC12 (CDC26) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386415
tested applications
ELISA
Description
Human Anaphase-Promoting Complex Subunit CDC26 / APC12 (CDC26) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human CDC26 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase-Promoting Complex Subunit CDC26 / APC12 (CDC26) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8NHZ8 |
| Gene ID | 246184 |
| OMIM | 614533 |
| Alias | CDC26, ANAPC12, C9orf17 |
| Background | Elisa kits for CDC26 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC12 (CDC26)is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that stabilizes the assembly of the complex and supports its ubiquitin ligase activity. ANAPC12 forms part of the platform that anchors other key components, ensuring the recruitment and interaction of co-activators such as CDC20 and CDH1 with substrates. Through its structural role, ANAPC12 helps mediate the ubiquitination of critical regulators such as cyclins, securin, and other proteins involved in cell cycle progression. ANAPC12 is required for proper activation of APC/C during metaphase-to-anaphase transition and mitotic exit. Dysregulation of ANAPC12 can impair APC/C activity, leading to mitotic defects, genomic instability, and increased susceptibility to cancer. Recent studies suggest that ANAPC12 may play additional roles in cellular stress responses and DNA damage repair, linking it to broader regulatory networks. Its importance in APC/C function highlights ANAPC12 as a critical factor for maintaining cell cycle fidelity and genomic integrity.
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