Human Anaphase Promoting Complex Subunit 5 (ANAPC5) ELISA Kit
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Description
Human Anaphase Promoting Complex Subunit 5 (ANAPC5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase Promoting Complex Subunit 5 (ANAPC5) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase Promoting Complex Subunit 5 (ANAPC5) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.05 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UJX4 |
| Gene ID | 51433 |
| OMIM | 606948 |
| Alias | ANAPC5,APC5,Cyclosome subunit 5 |
| Background | Elisa kits for ANAPC5 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC5 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) that contributes to the stability and assembly of the complex. It interacts with other subunits to form the platform necessary for substrate recognition and ubiquitination. ANAPC5 facilitates the recruitment of co-activators such as CDC20 and CDH1, which are required for targeting specific proteins for proteolysis during the cell cycle. By promoting the degradation of regulators like securin and cyclin B, ANAPC5 ensures proper chromosome segregation and mitotic exit. Loss or mutation of ANAPC5 impairs APC/C function, leading to cell cycle arrest, chromosomal instability, and an increased risk of cancer. ANAPC5’s role in the structural integrity of APC/C highlights its importance in maintaining genomic stability and normal cell division. Dysregulation of ANAPC5 is a hallmark of mitotic errors often observed in tumorigenesis.
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