Human Anaphase-promoting complex subunit 4 (ANAPC4) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Anaphase-promoting complex subunit 4 (ANAPC4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx502120
tested applications
ELISA
Description
Human Anaphase-promoting complex subunit 4 (ANAPC4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 4 (ANAPC4) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Anaphase-promoting complex subunit 4 (ANAPC4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9UJX5 |
| Alias | ANAPC4,APC4,Cyclosome subunit 4 |
| Background | Elisa kits for ANAPC4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ANAPC4 is a key structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that controls the progression of the cell cycle by targeting regulatory proteins for proteasomal degradation. ANAPC4 interacts with other core components, including ANAPC1 and ANAPC5, to form the scaffold that supports APC/C assembly and its enzymatic function. ANAPC4 plays an essential role in facilitating the ubiquitination of substrates such as cyclin B and securin, ensuring their degradation for the metaphase-to-anaphase transition and mitotic exit. Its proper function is necessary for maintaining chromosomal stability and preventing aneuploidy. Dysregulation of ANAPC4 leads to impaired APC/C activity, causing mitotic defects and genomic instability, which are strongly associated with tumorigenesis. ANAPC4 is emerging as a critical factor for cell division and a potential target for therapeutic intervention in proliferative diseases such as cancer.
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