Human Anaphase-promoting complex subunit 13 (ANAPC13) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC13
proveedor
Abbexareference
abx502109Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Anaphase-promoting complex subunit 13 (ANAPC13) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 13 (ANAPC13) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ANAPC13 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that regulates cell cycle progression. ANAPC13 plays a key role in stabilizing the APC/C complex by forming interactions with other core components, including ANAPC2 and ANAPC11, to facilitate the assembly and proper functioning of the complex. ANAPC13 supports the ubiquitination of substrates such as cyclin B and securin, ensuring their timely degradation to initiate the metaphase-to-anaphase transition and mitotic exit. Loss or mutation of ANAPC13 impairs APC/C activity, leading to chromosomal instability, cell cycle arrest, and increased risk of tumorigenesis. ANAPC13 also contributes to maintaining genomic integrity during mitosis, making it a critical component for cell division and proper cellular proliferation. Its structural role highlights its importance in APC/C-mediated proteolysis and cell cycle control.
Características del producto
category
ELISA Kits
immunogen target
Anaphase-promoting complex subunit 13 (ANAPC13)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
APC13,Cyclosome subunit 13
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC13
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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