Anaphase-Promoting Complex Subunit 13 (ANAPC13) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 13 (ANAPC13) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx135887
tested applications
WB
Description
ANAPC13 Antibody is a Rabbit Polyclonal against ANAPC13.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 13 (ANAPC13) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BS18 |
| Gene ID | 25847 |
| NCBI Accession | NP_056206.1 |
| Alias | APC13,Cyclosome subunit 13 |
| Background | Antibody anti-ANAPC13 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANAPC13 is a structural subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit E3 ubiquitin ligase that regulates cell cycle progression. ANAPC13 plays a key role in stabilizing the APC/C complex by forming interactions with other core components, including ANAPC2 and ANAPC11, to facilitate the assembly and proper functioning of the complex. ANAPC13 supports the ubiquitination of substrates such as cyclin B and securin, ensuring their timely degradation to initiate the metaphase-to-anaphase transition and mitotic exit. Loss or mutation of ANAPC13 impairs APC/C activity, leading to chromosomal instability, cell cycle arrest, and increased risk of tumorigenesis. ANAPC13 also contributes to maintaining genomic integrity during mitosis, making it a critical component for cell division and proper cellular proliferation. Its structural role highlights its importance in APC/C-mediated proteolysis and cell cycle control.
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