Human Anaphase-promoting complex subunit 1 (ANAPC1) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for ANAPC1
proveedor
Abbexareference
abx502100Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Anaphase-promoting complex subunit 1 (ANAPC1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Anaphase-promoting complex subunit 1 (ANAPC1) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
Background
ANAPC1 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a large E3 ubiquitin ligase complex that regulates the progression of the cell cycle. ANAPC1 serves as a structural scaffold that supports the assembly and stability of the APC/C complex. The APC/C targets key cell cycle regulators such as cyclin B and securin for ubiquitin-mediated proteasomal degradation, ensuring the timely transition from metaphase to anaphase and promoting exit from mitosis. ANAPC1 is essential for maintaining chromosomal stability and proper segregation of sister chromatids during mitosis. Mutations or dysregulation of ANAPC1 have been linked to genomic instability, aneuploidy, and the development of cancers. Studies also suggest that defects in ANAPC1 can contribute to neurodevelopmental disorders and tissue-specific growth abnormalities due to impaired cell cycle regulation. Its central role in cell division highlights ANAPC1 as a potential therapeutic target for cancer and proliferative diseases.
Características del producto
category
ELISA Kits
immunogen target
Anaphase-promoting complex subunit 1 (ANAPC1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.
size 1
96 tests
alias
ANAPC1,TSG24,APC1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
ANAPC1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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