Anaphase-Promoting Complex Subunit 1 (ANAPC1) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Anaphase-Promoting Complex Subunit 1 (ANAPC1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx012953
tested applications
ELISA, IHC
Description
Rabbit polyclonal antibody against APC1 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Anaphase-Promoting Complex Subunit 1 (ANAPC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IHC: 1/50 - 1/100, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9H1A4 |
| Alias | ANAPC1,TSG24,APC1 |
| Background | Antibody anti-ANAPC1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ANAPC1 is a core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), a large E3 ubiquitin ligase complex that regulates the progression of the cell cycle. ANAPC1 serves as a structural scaffold that supports the assembly and stability of the APC/C complex. The APC/C targets key cell cycle regulators such as cyclin B and securin for ubiquitin-mediated proteasomal degradation, ensuring the timely transition from metaphase to anaphase and promoting exit from mitosis. ANAPC1 is essential for maintaining chromosomal stability and proper segregation of sister chromatids during mitosis. Mutations or dysregulation of ANAPC1 have been linked to genomic instability, aneuploidy, and the development of cancers. Studies also suggest that defects in ANAPC1 can contribute to neurodevelopmental disorders and tissue-specific growth abnormalities due to impaired cell cycle regulation. Its central role in cell division highlights ANAPC1 as a potential therapeutic target for cancer and proliferative diseases.
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