Human Aminoacylase 3 (ACY3) Protein
390€ (10 µg)
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935106861
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name
Human Aminoacylase 3 (ACY3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692941
tested applications
SDS-PAGE
Description
Human N-Acyl-Aromatic-L-Amino Acid Amidohydrolase Protein is a recombinant protein from Human produced in E. coli. Recombinant Human N-acyl-aromatic-L-amino acid amidohydrolase is produced by our E.coli expression system and the target gene encoding Met1-Ser319 is expressed with a 6His tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | N-Acyl-Aromatic-L-Amino Acid Amidohydrolase |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 37.4 kDa Sequence Fragment: Met1-Ser319 Tag: N-terminal 6 His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM Tris, 100mM NaCl, 1mM DTT, 10%Glycerol, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96HD9 |
| Alias | ACY-3,HCBP1,Aspartoacylase 2 |
| Background | Protein ACY3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACY3 is a cytosolic and mitochondrial enzyme involved in the hydrolysis of N-acylated amino acids, particularly those associated with glutamate and aspartate, into free amino acids and their acyl groups. This enzyme is primarily expressed in the kidneys and liver, where it supports amino acid metabolism and the detoxification of metabolic byproducts. ACY3 plays a role in maintaining cellular amino acid pools and regulating nitrogen metabolism, contributing to processes like gluconeogenesis and energy production. It is also involved in clearing N-acetylated intermediates that accumulate during amino acid catabolism. Dysregulation of ACY3 has been implicated in kidney function abnormalities and metabolic disorders, where disruptions in amino acid metabolism can lead to imbalances in energy homeostasis. Its dual localization and specificity for acidic N-acylated amino acids highlight its specialized function in amino acid processing and metabolic regulation.
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