Human Alpha-Methylacyl Coenzyme A Racemase (aMACR) Protein

Este producto es parte de AMACR - Alpha-methylacyl-CoA racemase
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247€ (10 µg)

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935106861
info@markelab.com
name
Human Alpha-Methylacyl Coenzyme A Racemase (aMACR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650768
tested applications
WB, SDS-PAGE

Description

Human aMACR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Alpha-Methylacyl Coenzyme A Racemase (aMACR)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 19.7 kDa  Observed MW (SDS-PAGE): 20 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ala2-Asn148

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9UHK6
Alias
AMACR
Background
Protein AMACR
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.

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