Human Alpha-Methylacyl Coenzyme A Racemase (aMACR) Protein

Este producto es parte de AMACR - Alpha-methylacyl-CoA racemase
Human Alpha-Methylacyl Coenzyme A Racemase (aMACR) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein AMACR

proveedor

Abbexa

reference

abx650768

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human aMACR Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Alpha-Methylacyl Coenzyme A Racemase (aMACR)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.7 kDa Observed MW (SDS-PAGE): 20 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala2-Asn148 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AMACR


dry ice

No


availability

Shipped within 5-7 working days.


alias

AMACR


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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