AMACR antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alpha-methylacyl-CoA racemase (AMACR) |
| Host | Rabbit |
| Reactivity | Human, rat |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 42 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UHK6 |
| Alias | AMACR |
| Background | Antibody anti-AMACR |
| Status | RUO |
| Note | Mol. Weight 42 kDa |
Descripción
Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.
Related Products
Human AMACR (Alpha-methylacyl-CoA racemase) ELISA Kit
Ver Producto
AMACR antibody
AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Ver Producto