Human Alpha-Hemoglobin Stabilizing Protein (aHSP) Protein

Este producto es parte de AHSP - Alpha Hemoglobin Stabilizing Protein
Human Alpha-Hemoglobin Stabilizing Protein (aHSP) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein AHSP

proveedor

Abbexa

reference

abx065284

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Alpha-Hemoglobin Stabilizing Protein (aHSP) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Alpha Hemoglobin Stabilizing Protein (AHSP) is a molecular chaperone that specifically binds to free alpha-globin subunits during erythropoiesis, stabilizing them and preventing their aggregation or precipitation. This function is critical for maintaining the proper stoichiometry of alpha- and beta-globin chains required for the assembly of functional hemoglobin tetramers. AHSP also protects alpha-globin from oxidative damage by maintaining it in a reduced state. Dysregulation or deficiency of AHSP is associated with hematological disorders such as beta-thalassemia, where excess alpha-globin chains lead to oxidative stress and ineffective erythropoiesis. AHSP is highly expressed in erythroid precursor cells, and its expression is tightly regulated during red blood cell development. Therapeutic approaches that modulate AHSP levels or function are being explored as potential treatments for thalassemias and related hemoglobinopathies.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Alpha-Hemoglobin Stabilizing Protein (aHSP)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 17.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser102 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AHSP


dry ice

No


availability

Shipped within 5-12 working days.


alias

EDRF,ERAF


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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