Human Alpha-Hemoglobin Stabilizing Protein (aHSP) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human Alpha-Hemoglobin Stabilizing Protein (aHSP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065284
tested applications
WB, SDS-PAGE
Description
Recombinant Alpha-Hemoglobin Stabilizing Protein (aHSP) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alpha-Hemoglobin Stabilizing Protein (aHSP) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 17.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Ser102 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZD4 |
| Alias | EDRF,ERAF |
| Background | Protein AHSP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Alpha Hemoglobin Stabilizing Protein (AHSP) is a molecular chaperone that specifically binds to free alpha-globin subunits during erythropoiesis, stabilizing them and preventing their aggregation or precipitation. This function is critical for maintaining the proper stoichiometry of alpha- and beta-globin chains required for the assembly of functional hemoglobin tetramers. AHSP also protects alpha-globin from oxidative damage by maintaining it in a reduced state. Dysregulation or deficiency of AHSP is associated with hematological disorders such as beta-thalassemia, where excess alpha-globin chains lead to oxidative stress and ineffective erythropoiesis. AHSP is highly expressed in erythroid precursor cells, and its expression is tightly regulated during red blood cell development. Therapeutic approaches that modulate AHSP levels or function are being explored as potential treatments for thalassemias and related hemoglobinopathies.
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