Human Alpha-Hemoglobin-stabilizing protein (AHSP) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
585€ (96 tests)
Elisa kits for AHSP
proveedor
Abbexareference
abx253378Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Alpha-Hemoglobin-stabilizing protein (AHSP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alpha-Hemoglobin Stabilizing Protein concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Alpha Hemoglobin Stabilizing Protein (AHSP) is a molecular chaperone that specifically binds to free alpha-globin subunits during erythropoiesis, stabilizing them and preventing their aggregation or precipitation. This function is critical for maintaining the proper stoichiometry of alpha- and beta-globin chains required for the assembly of functional hemoglobin tetramers. AHSP also protects alpha-globin from oxidative damage by maintaining it in a reduced state. Dysregulation or deficiency of AHSP is associated with hematological disorders such as beta-thalassemia, where excess alpha-globin chains lead to oxidative stress and ineffective erythropoiesis. AHSP is highly expressed in erythroid precursor cells, and its expression is tightly regulated during red blood cell development. Therapeutic approaches that modulate AHSP levels or function are being explored as potential treatments for thalassemias and related hemoglobinopathies.
Características del producto
category
ELISA Kits
immunogen target
Alpha-Hemoglobin-stabilizing protein (AHSP)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
0.1 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
EDRF,ERAF
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AHSP
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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