Human Alpha Adducin (ADD1) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ADD1
proveedor
Abbexareference
abx168875Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Alpha Adducin (ADD1) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli). Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C.
Background
ADD1 encodes alpha-adducin, a cytoskeletal protein that plays a key role in the assembly and maintenance of the actin-spectrin network, a critical component of the cell cortex. Alpha-adducin is primarily expressed in the brain and kidneys, where it contributes to cellular processes such as membrane stability, ion transport regulation, and cell signaling. It is particularly important in erythrocytes, where it stabilizes the spectrin-actin lattice to maintain red blood cell shape and flexibility. Genetic variations in ADD1 have been associated with hypertension and cardiovascular diseases due to its role in modulating sodium transport in renal epithelial cells. Additionally, alpha-adducin is involved in neuronal morphology and synaptic plasticity, highlighting its importance in neural development and function. Dysregulation or mutations can lead to cellular structural defects and associated diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Alpha Adducin (ADD1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr99-Gln328 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ADD1
dry ice
No
availability
Shipped within 5-7 working days.
alias
ADDA,ADDUCIN 1
uniprot id
NCBI accession
NP_001110.2, NM_001119.4
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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