ADD1 (Phospho-Ser726) Antibody
52€ (10 µg)
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Name
ADD1 (Phospho-Ser726) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012401
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
Rabbit polyclonal antibody against ADD1 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:S726/S713, M:S724/S712, R:S724/S712.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: ADD1 Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human ADD1around the phosphorylation site of serine 726 (T-P-SP-F-L). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 3000, IHC: 1/50 - 100, IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35611, P35612 |
| Alias | ADDA,ADDUCIN 1 |
| Background | Antibody anti-ADD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADD1 encodes alpha-adducin, a cytoskeletal protein that plays a key role in the assembly and maintenance of the actin-spectrin network, a critical component of the cell cortex. Alpha-adducin is primarily expressed in the brain and kidneys, where it contributes to cellular processes such as membrane stability, ion transport regulation, and cell signaling. It is particularly important in erythrocytes, where it stabilizes the spectrin-actin lattice to maintain red blood cell shape and flexibility. Genetic variations in ADD1 have been associated with hypertension and cardiovascular diseases due to its role in modulating sodium transport in renal epithelial cells. Additionally, alpha-adducin is involved in neuronal morphology and synaptic plasticity, highlighting its importance in neural development and function. Dysregulation or mutations can lead to cellular structural defects and associated diseases.
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