Human Alpha-1-Antichymotrypsin (SERPINA3) Protein
234€ (5 µg)
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name
Human Alpha-1-Antichymotrypsin (SERPINA3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx260557
tested applications
SDS-PAGE
Description
SERPINA3 is a recombinant protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Alpha-1-Antichymotrypsin (SERPINA3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: 24-423 AA. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 5 µg |
| Size 2 | 25 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl buffer, pH 8, containing 1 mM DTT and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01011 |
| Gene ID | 12 |
| NCBI Accession | NP_001076.2, NM_001085.4 |
| OMIM | 107280 |
| Alias | ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3 |
| Background | Protein SERPINA3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SERPINA3, also known as alpha-1 antichymotrypsin (ACT), is a member of the serine protease inhibitor (serpin) superfamily. The SERPINA3 gene is located on chromosome 14 (14q32.13), in close proximity to other serpin genes, including SERPINA1, which encodes alpha-1 antitrypsin. SERPINA3 plays a crucial role in inhibiting the activity of certain proteases, particularly cathepsin G and chymotrypsin, enzymes involved in inflammation and immune responses. The protein encoded by SERPINA3 is predominantly synthesized in the liver, but it is also expressed in various other tissues, including the brain, lungs, and immune cells. SERPINA3 has been implicated in a variety of physiological and pathological processes, such as inflammation, tissue remodeling, and the acute phase response. It is also known for its association with neurodegenerative diseases, particularly Alzheimer's disease, where it is found in amyloid plaques.
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