SERPINA3 is a recombinant protein.
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). SERPINA3, also called α-1-antichymotrypsin (AACT, ACT), is one of the inhibitors of serine proteases, one of which is cathepsin G. Elevated levels of SERPINA3 have been observed in heart failure and neurological diseases such as Alzheimer’s disease
Proteins and Peptides
Human
E. coli
Alpha-1-Antichymotrypsin (SERPINA3)
E. coli
Unconjugated
Liquid
SDS-PAGE
5 µg
25 µg
1 mg
Recombinant
> 95% (SDS-PAGE)
Purified by proprietary chromatographic techniques.
20 mM Tris-HCl buffer, pH 8, containing 1 mM DTT and 10% glycerol.
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
SERPINA3
No
Shipped within 5-10 working days.
ACT,AACT,GIG24,GIG25,Alpha-1-antichymotrypsin,Cell growth-inhibiting gene 24/25 protein,Serpin A3
NP_001076.2, NM_001085.4
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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