Human AlkB Homolog 4, Lysine Demethylase (ALKBH4) ELISA Kit

Este producto es parte de ALKBH - alkB homolog
Human AlkB Homolog 4, Lysine Demethylase (ALKBH4) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for ALKBH4

proveedor

Abbexa

reference

abx385716

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human AlkB Homolog 4, Lysine Demethylase (ALKBH4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human AlkB, Alkylation Repair Homolog 4 (ALKBH4) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

ALKBH4 is a nuclear enzyme that functions as a lysine demethylase, specifically targeting methylated lysine residues on non-histone proteins. ALKBH4 plays a critical role in cytoskeletal dynamics, particularly by demethylating actin, which regulates actin filament assembly and cellular motility. Its activity ensures proper cytokinesis, cell shape maintenance, and migration during mitosis and development. ALKBH4 also participates in DNA repair and gene regulation by interacting with other proteins involved in chromatin remodeling and transcription. Dysregulation of ALKBH4 is linked to defects in cell division, genomic instability, and impaired cellular motility, contributing to developmental abnormalities and cancer progression. In cancer biology, ALKBH4’s regulation of cytoskeletal dynamics has been shown to promote cancer cell invasion and metastasis. Its role in demethylating non-histone proteins distinguishes ALKBH4 from other ALKB family members, highlighting its importance in post-translational modification and cellular homeostasis.

Características del producto

category

ELISA Kits


immunogen target

AlkB Homolog 4, Lysine Demethylase (ALKBH4)


reactivity

Human


test range

0.313 ng/ml - 20 ng/ml


sensitivity

< 0.19 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

ALKBH4,ABH4


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

ALKBH4


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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