Human AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits ALKBH3
proveedor
Abbexareference
abx385715Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human AlkB, Alkylation Repair Homolog 3 (ALKBH3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
ALKBH3 is an α-KG- and Fe(II)-dependent dioxygenase that repairs methylated lesions on single-stranded DNA (ssDNA) and RNA. It specifically removes alkylation damage, such as N1-methyladenine (m1A) and N3-methylcytosine (m3C), restoring nucleic acid integrity and ensuring proper transcription and translation. ALKBH3 exhibits a preference for repairing damage in RNA, including tRNA, rRNA, and mRNA, where it preserves their structural stability and functionality. ALKBH3 interacts with ASCC3 helicase, which unwinds damaged regions of DNA/RNA, facilitating repair. Its role in RNA demethylation highlights its importance in regulating gene expression and protein synthesis. Overexpression of ALKBH3 has been observed in various cancers, including prostate, pancreatic, and lung cancers, where it contributes to tumor cell proliferation, survival, and resistance to alkylating agents. Targeting ALKBH3 has been explored as a therapeutic approach for sensitizing cancer cells to chemotherapy and inhibiting tumor growth.
Características del producto
category
ELISA Kits
immunogen target
AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
ALKBH3,ABH3,DEPC1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
ALKBH3
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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