ALKBH3 antibody

Este producto es parte de ALKBH - alkB homolog
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
ALKBH3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00312
tested applications
ELISA, WB, IHC

Description

ALKBH3, also named as ABH3 and DEPC-1, is a dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). It has a strong preference for single-stranded. ALKBH3 is requires molecular oxygen, alpha-ketoglutarate and iron. This gene has some isoforms with MW 19-25 kDa and 33 kDa.

Documents del producto

Instrucciones
Descargar
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
alkB, alkylation repair homolog 3(E. coli) (ALKBH3)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:5000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
33 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q96Q83
Gene ID
221120
Alias
ALKBH3,ABH3,DEPC1
Background
Antibody anti-ALKBH3
Status
RUO
Note
Mol. Weight 33 kDa

Descripción

ALKBH3 is an α-KG- and Fe(II)-dependent dioxygenase that repairs methylated lesions on single-stranded DNA (ssDNA) and RNA. It specifically removes alkylation damage, such as N1-methyladenine (m1A) and N3-methylcytosine (m3C), restoring nucleic acid integrity and ensuring proper transcription and translation. ALKBH3 exhibits a preference for repairing damage in RNA, including tRNA, rRNA, and mRNA, where it preserves their structural stability and functionality. ALKBH3 interacts with ASCC3 helicase, which unwinds damaged regions of DNA/RNA, facilitating repair. Its role in RNA demethylation highlights its importance in regulating gene expression and protein synthesis. Overexpression of ALKBH3 has been observed in various cancers, including prostate, pancreatic, and lung cancers, where it contributes to tumor cell proliferation, survival, and resistance to alkylating agents. Targeting ALKBH3 has been explored as a therapeutic approach for sensitizing cancer cells to chemotherapy and inhibiting tumor growth.

Related Products

FNab00312

ALKBH3 antibody

ALKBH3, also named as ABH3 and DEPC-1, is a dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). It has a strong preference for single-stranded. ALKBH3 is requires molecular oxygen, alpha-ketoglutarate and iron. This gene has some isoforms with MW 19-25 kDa and 33 kDa.

Ver Producto
abx004450

AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody

ALKBH3 Antibody is a Rabbit Polyclonal antibody against ALKBH3. The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002.

Ver Producto
abx034060

AlkB Homolog 3, Alpha-Ketoglutaratedependent Dioxygenase (ALKBH3) Antibody

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine.

Ver Producto