Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Protein
338€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692835
tested applications
SDS-PAGE
Description
Human Aldo-Keto Reductase 1C4 Protein is a recombinant protein from Human produced in E. coli. Recombinant Human Aldo-Keto Reductase Family 1 Member C4 is produced by our E.coli expression system and the target gene encoding Met1-Tyr323 is expressed with a 6His tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase 1C4 |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 39.3 kDa Sequence Fragment: Met1-Tyr323 Tag: N-terminal 6 His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM TrisHCl, 150mM NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17516 |
| Alias | AKR1C4, CHDR |
| Background | Protein AKR1C4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AKR1C4 is primarily expressed in the liver and functions as a key enzyme in bile acid biosynthesis and steroid metabolism. It catalyzes the reduction of ketosteroids, including androgens, estrogens, and progestins, to their inactive metabolites, maintaining steroid hormone balance. AKR1C4 is highly active in converting 5α-dihydrotestosterone (DHT) and progesterone to their respective inactive 3α-hydroxy derivatives, thus playing a protective role in preventing excessive androgen and progesterone signaling. Its liver-specific expression makes it central to hepatic detoxification, where it metabolizes reactive carbonyl species and exogenous toxins, protecting hepatocytes from oxidative stress. Dysregulation of AKR1C4 has been associated with liver diseases, including hepatocellular carcinoma, where it contributes to metabolic reprogramming and tumor progression. AKR1C4 also influences bile acid synthesis and lipid metabolism, highlighting its role in maintaining liver homeostasis. Its involvement in steroid and detoxification pathways makes it a potential target for liver diseases and hormone-related disorders.
Related Products
Human AKR1C4 (Aldo-keto reductase family 1 member C4) ELISA Kit
Ver Producto
AKR1C4 antibody
Catalyzes the transformation of the potent androgen dihydrotestosterone(DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol(3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone(kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Ver Producto