Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Protein
338€ (10 µg)
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Name
Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692835
Tested Applications
SDS-PAGE
Description
Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Tyr323 Tag: N-terminal 6 His tag |
| Origin | Human |
| Observed MW | 39.3 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM TrisHCl, 150 mM NaCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| UniProt ID | P17516 |
| Alias | AKR1C4, CHDR |
| Background | Protein AKR1C4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
AKR1C4 is primarily expressed in the liver and functions as a key enzyme in bile acid biosynthesis and steroid metabolism. It catalyzes the reduction of ketosteroids, including androgens, estrogens, and progestins, to their inactive metabolites, maintaining steroid hormone balance. AKR1C4 is highly active in converting 5α-dihydrotestosterone (DHT) and progesterone to their respective inactive 3α-hydroxy derivatives, thus playing a protective role in preventing excessive androgen and progesterone signaling. Its liver-specific expression makes it central to hepatic detoxification, where it metabolizes reactive carbonyl species and exogenous toxins, protecting hepatocytes from oxidative stress. Dysregulation of AKR1C4 has been associated with liver diseases, including hepatocellular carcinoma, where it contributes to metabolic reprogramming and tumor progression. AKR1C4 also influences bile acid synthesis and lipid metabolism, highlighting its role in maintaining liver homeostasis. Its involvement in steroid and detoxification pathways makes it a potential target for liver diseases and hormone-related disorders.
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