Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Antibody
195€ (20 µl)
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name
Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006948
tested applications
ELISA, WB
Description
AKR1C4 Antibody is a Rabbit Polyclonal Antibody against AKR1C4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17516 |
| Gene ID | 1109 |
| NCBI Accession | NP_001809.3 |
| Alias | AKR1C4, CHDR |
| Background | Antibody anti-AKR1C4 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
AKR1C4 is primarily expressed in the liver and functions as a key enzyme in bile acid biosynthesis and steroid metabolism. It catalyzes the reduction of ketosteroids, including androgens, estrogens, and progestins, to their inactive metabolites, maintaining steroid hormone balance. AKR1C4 is highly active in converting 5α-dihydrotestosterone (DHT) and progesterone to their respective inactive 3α-hydroxy derivatives, thus playing a protective role in preventing excessive androgen and progesterone signaling. Its liver-specific expression makes it central to hepatic detoxification, where it metabolizes reactive carbonyl species and exogenous toxins, protecting hepatocytes from oxidative stress. Dysregulation of AKR1C4 has been associated with liver diseases, including hepatocellular carcinoma, where it contributes to metabolic reprogramming and tumor progression. AKR1C4 also influences bile acid synthesis and lipid metabolism, highlighting its role in maintaining liver homeostasis. Its involvement in steroid and detoxification pathways makes it a potential target for liver diseases and hormone-related disorders.
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