Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx251567
tested applications
ELISA
Description
Human Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldo-keto reductase family 1 member C4 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member C4 (AKR1C4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P17516 |
| Alias | AKR1C4, CHDR |
| Background | Elisa Kits for: AKR1C4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
AKR1C4 is primarily expressed in the liver and functions as a key enzyme in bile acid biosynthesis and steroid metabolism. It catalyzes the reduction of ketosteroids, including androgens, estrogens, and progestins, to their inactive metabolites, maintaining steroid hormone balance. AKR1C4 is highly active in converting 5α-dihydrotestosterone (DHT) and progesterone to their respective inactive 3α-hydroxy derivatives, thus playing a protective role in preventing excessive androgen and progesterone signaling. Its liver-specific expression makes it central to hepatic detoxification, where it metabolizes reactive carbonyl species and exogenous toxins, protecting hepatocytes from oxidative stress. Dysregulation of AKR1C4 has been associated with liver diseases, including hepatocellular carcinoma, where it contributes to metabolic reprogramming and tumor progression. AKR1C4 also influences bile acid synthesis and lipid metabolism, highlighting its role in maintaining liver homeostasis. Its involvement in steroid and detoxification pathways makes it a potential target for liver diseases and hormone-related disorders.
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