Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) Protein
234€ (5 µg)
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name
Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073516
tested applications
SDS-PAGE
Description
Aldo-Keto Reductase Family 1 Member B10 is a recombinant enzyme.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60218 |
| Alias | AKR1B10,AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1 |
| Background | Protein AKR1B10 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AKR1B10 is primarily expressed in the liver, intestines, and lungs, where it catalyzes the reduction of carbonyl compounds, including aldehydes derived from lipid peroxidation and retinoic acid metabolism. AKR1B10 plays a pivotal role in detoxifying reactive aldehydes, thereby protecting cells from oxidative stress and lipid damage. It also regulates cellular retinoic acid levels, influencing cell proliferation, differentiation, and apoptosis. Overexpression of AKR1B10 is strongly associated with various cancers, particularly hepatocellular carcinoma (HCC), non-small-cell lung cancer (NSCLC), and colorectal cancer, where it enhances tumor progression, chemoresistance, and metastasis. AKR1B10 contributes to drug resistance by metabolizing chemotherapeutic agents and supporting lipid synthesis for tumor growth. Its role in fatty acid biosynthesis links it to metabolic reprogramming in cancer cells, promoting proliferation and survival. AKR1B10 is considered a promising biomarker for cancer diagnosis and prognosis, as well as a therapeutic target for improving cancer treatment outcomes.
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