Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) Protein

Este producto es parte de AKR1B - Aldo-keto reductase family 1 member B
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234€ (5 µg)

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935106861
info@markelab.com
name
Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx073516
tested applications
SDS-PAGE

Description

Aldo-Keto Reductase Family 1 Member B10 is a recombinant enzyme.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryProteins and Peptides
Immunogen TargetAldo-Keto Reductase Family 1 Member B10 (AKR1B10)
HostE. coli
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
OriginHuman
ExpressionRecombinant
Purity> 95% (SDS-PAGE)
Size 15 µg
Size 220 µg
Size 31 mg
FormLiquid
Tested ApplicationsSDS-PAGE
AvailabilityShipped within 5-10 working days.
StorageStore at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDO60218
AliasAKR1B10,AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1
BackgroundProtein AKR1B10
StatusRUO
NoteThis product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

AKR1B10 is primarily expressed in the liver, intestines, and lungs, where it catalyzes the reduction of carbonyl compounds, including aldehydes derived from lipid peroxidation and retinoic acid metabolism. AKR1B10 plays a pivotal role in detoxifying reactive aldehydes, thereby protecting cells from oxidative stress and lipid damage. It also regulates cellular retinoic acid levels, influencing cell proliferation, differentiation, and apoptosis. Overexpression of AKR1B10 is strongly associated with various cancers, particularly hepatocellular carcinoma (HCC), non-small-cell lung cancer (NSCLC), and colorectal cancer, where it enhances tumor progression, chemoresistance, and metastasis. AKR1B10 contributes to drug resistance by metabolizing chemotherapeutic agents and supporting lipid synthesis for tumor growth. Its role in fatty acid biosynthesis links it to metabolic reprogramming in cancer cells, promoting proliferation and survival. AKR1B10 is considered a promising biomarker for cancer diagnosis and prognosis, as well as a therapeutic target for improving cancer treatment outcomes.

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