Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
562.5€ (96 tests)
Elisa Kits AKR1B10
proveedor
Abbexareference
abx515123Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldose Reductase Like Protein 1 concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Background
AKR1B10 is primarily expressed in the liver, intestines, and lungs, where it catalyzes the reduction of carbonyl compounds, including aldehydes derived from lipid peroxidation and retinoic acid metabolism. AKR1B10 plays a pivotal role in detoxifying reactive aldehydes, thereby protecting cells from oxidative stress and lipid damage. It also regulates cellular retinoic acid levels, influencing cell proliferation, differentiation, and apoptosis. Overexpression of AKR1B10 is strongly associated with various cancers, particularly hepatocellular carcinoma (HCC), non-small-cell lung cancer (NSCLC), and colorectal cancer, where it enhances tumor progression, chemoresistance, and metastasis. AKR1B10 contributes to drug resistance by metabolizing chemotherapeutic agents and supporting lipid synthesis for tumor growth. Its role in fatty acid biosynthesis links it to metabolic reprogramming in cancer cells, promoting proliferation and survival. AKR1B10 is considered a promising biomarker for cancer diagnosis and prognosis, as well as a therapeutic target for improving cancer treatment outcomes.
Características del producto
category
ELISA Kits
immunogen target
Aldo-Keto Reductase Family 1 Member B10 (AKR1B10)
reactivity
Human
test range
78 pg/ml - 5000 pg/ml
sensitivity
46.9 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
AKR1B10,AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
AKR1B10
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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