Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) ELISA Kit

Este producto es parte de AKR1B - Aldo-keto reductase family 1 member B
Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

562.5€ (96 tests)

Elisa Kits AKR1B10

proveedor

Abbexa

reference

abx515123

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldose Reductase Like Protein 1 concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.


Background

AKR1B10 is primarily expressed in the liver, intestines, and lungs, where it catalyzes the reduction of carbonyl compounds, including aldehydes derived from lipid peroxidation and retinoic acid metabolism. AKR1B10 plays a pivotal role in detoxifying reactive aldehydes, thereby protecting cells from oxidative stress and lipid damage. It also regulates cellular retinoic acid levels, influencing cell proliferation, differentiation, and apoptosis. Overexpression of AKR1B10 is strongly associated with various cancers, particularly hepatocellular carcinoma (HCC), non-small-cell lung cancer (NSCLC), and colorectal cancer, where it enhances tumor progression, chemoresistance, and metastasis. AKR1B10 contributes to drug resistance by metabolizing chemotherapeutic agents and supporting lipid synthesis for tumor growth. Its role in fatty acid biosynthesis links it to metabolic reprogramming in cancer cells, promoting proliferation and survival. AKR1B10 is considered a promising biomarker for cancer diagnosis and prognosis, as well as a therapeutic target for improving cancer treatment outcomes.

Características del producto

category

ELISA Kits


immunogen target

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10)


reactivity

Human


test range

78 pg/ml - 5000 pg/ml


sensitivity

46.9 pg/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids


size 1

96 tests


alias

AKR1B10,AKR1B11,AKR1B12,ALDRLn,ARL-1,ARL1


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

AKR1B10


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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