Human Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385699
tested applications
ELISA
Description
Human Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P47895 |
| Gene ID | 220 |
| OMIM | 600463 |
| Alias | ALDH1A3, ALDH6 |
| Background | Elisa kits for ALDH1A3 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALDH1A3 is a cytosolic enzyme that catalyzes the irreversible oxidation of retinaldehyde to retinoic acid, an essential signaling molecule that regulates gene expression during development, tissue homeostasis, and differentiation. ALDH1A3 plays a pivotal role in retinoic acid synthesis, particularly in the nervous system, epithelial tissues, and metabolic organs. Its expression is highly regulated during embryogenesis, where it influences organ patterning, neurogenesis, and craniofacial development. ALDH1A3 is often overexpressed in various cancers, including glioblastoma, breast cancer, and lung cancer, where it functions as a marker for cancer stem cells (CSCs), promoting tumor initiation, chemoresistance, and metastasis. Beyond its role in cancer, ALDH1A3 is involved in lipid and glucose metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and diabetes. Recent studies highlight ALDH1A3 as a potential therapeutic target for blocking CSC-mediated tumor progression and metabolic dysfunction.
Related Products
anti- ALDH1A3 antibody
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system(By similarity).
Ver Producto
Recombinant Human ALDH1A3
Ver Producto
Aldehyde Dehydrogenase Family 1 Member A3 (ALDH1A3) Antibody
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein form.
Ver Producto