Human Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) Protein
208€ (10 µg)
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935106861
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name
Human Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065213
tested applications
WB, SDS-PAGE
Description
Recombinant Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aldehyde Dehydrogenase 1 Family, Member A3 (ALDH1A3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 21.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg332-Asp509 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P47895 |
| Alias | ALDH1A3, ALDH6 |
| Background | Protein ALDH1A3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ALDH1A3 is a cytosolic enzyme that catalyzes the irreversible oxidation of retinaldehyde to retinoic acid, an essential signaling molecule that regulates gene expression during development, tissue homeostasis, and differentiation. ALDH1A3 plays a pivotal role in retinoic acid synthesis, particularly in the nervous system, epithelial tissues, and metabolic organs. Its expression is highly regulated during embryogenesis, where it influences organ patterning, neurogenesis, and craniofacial development. ALDH1A3 is often overexpressed in various cancers, including glioblastoma, breast cancer, and lung cancer, where it functions as a marker for cancer stem cells (CSCs), promoting tumor initiation, chemoresistance, and metastasis. Beyond its role in cancer, ALDH1A3 is involved in lipid and glucose metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and diabetes. Recent studies highlight ALDH1A3 as a potential therapeutic target for blocking CSC-mediated tumor progression and metabolic dysfunction.
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