Human Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) Protein
1404€ (100 µg)
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Name
Human Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693708
Tested Applications
SDS-PAGE
Description
Human ALDH4A1 Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human ALDH4A1 (AAH07581.1) (Lys 25-Gln 563) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ALDH4A1 |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Lys25-Gln563 |
| Origin | Human |
| Observed MW | 59.2 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | AAH07581.1 |
| Alias | P5C dehydrogenase |
| Background | Protein ALDH4A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
ALDH4A1, also known as pyrroline-5-carboxylate dehydrogenase (P5CDH), is a mitochondrial enzyme that catalyzes the conversion of pyrroline-5-carboxylate (P5C) into glutamate as part of the proline degradation pathway. This reaction is critical for maintaining amino acid metabolism, nitrogen balance, and cellular energy production. ALDH4A1 is expressed in tissues such as the liver, kidneys, and muscles, where proline serves as a key energy substrate. Mutations in ALDH4A1 lead to hyperprolinemia type II, a rare metabolic disorder characterized by elevated levels of proline and P5C, causing neurological symptoms, seizures, and cognitive impairments. ALDH4A1 also plays a role in protecting cells from oxidative stress, as proline metabolism generates NADH, which supports mitochondrial function. Its regulation is critical for amino acid catabolism, energy balance, and stress responses under nutrient deprivation.
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