anti- ALDH1A3 antibody
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935106861
info@markelab.com
name
anti- ALDH1A3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00286
tested applications
ELISA, WB, IHC, IF
Description
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | aldehyde dehydrogenase 1 family, member A3 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 56 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P47895 |
| Gene ID | 220 |
| Alias | ALDH1A3, ALDH6 |
| Background | Antibody anti-ALDH1A3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
ALDH1A3 is a cytosolic enzyme that catalyzes the irreversible oxidation of retinaldehyde to retinoic acid, an essential signaling molecule that regulates gene expression during development, tissue homeostasis, and differentiation. ALDH1A3 plays a pivotal role in retinoic acid synthesis, particularly in the nervous system, epithelial tissues, and metabolic organs. Its expression is highly regulated during embryogenesis, where it influences organ patterning, neurogenesis, and craniofacial development. ALDH1A3 is often overexpressed in various cancers, including glioblastoma, breast cancer, and lung cancer, where it functions as a marker for cancer stem cells (CSCs), promoting tumor initiation, chemoresistance, and metastasis. Beyond its role in cancer, ALDH1A3 is involved in lipid and glucose metabolism, and its dysregulation has been linked to metabolic disorders such as obesity and diabetes. Recent studies highlight ALDH1A3 as a potential therapeutic target for blocking CSC-mediated tumor progression and metabolic dysfunction.
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