Human Alcohol Dehydrogenase 2 (ADH2) Protein
208€ (10 µg)
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Name
Human Alcohol Dehydrogenase 2 (ADH2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx652443
Tested Applications
WB, SDS-PAGE
Description
Human Alcohol Dehydrogenase 2 (ADH2) Protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Alcohol Dehydrogenase 2 (ADH2) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser2-Phe375 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | ADH1B,ADH2, HEL-S-117 |
| Background | Protein ADH1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
ADH1B encodes the beta subunit of class I ADH enzymes, which are highly active in the oxidation of ethanol to acetaldehyde. This subunit is particularly important in liver and stomach tissues, where alcohol metabolism is initiated. Polymorphisms in the ADH1B gene, such as the ADH1B2 and ADH1B3 variants, are known to significantly alter enzyme activity. These variants exhibit faster ethanol oxidation rates and are associated with reduced risks of alcohol dependence and increased susceptibility to alcohol-induced flushing. ADH1B also participates in the metabolism of other alcohols and aldehydes, influencing various physiological and pathological processes. Its role in retinol metabolism connects it to pathways involved in vision and cell differentiation. Dysregulation of ADH1B activity has implications for alcohol-related liver diseases and certain cancers, particularly those of the gastrointestinal tract, where acetaldehyde accumulation is a risk factor.
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