Alcohol Dehydrogenase 1B (ADH1B) Antibody
312€ (60 µl)
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Name
Alcohol Dehydrogenase 1B (ADH1B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001235
Tested Applications
WB
Description
ADH1B Antibody is a Rabbit Polyclonal antibody against ADH1B. The ADH1B gene encodes the beta subunit of class I alcohol dehydrogenase (ADH), an enzyme that catalyzes the rate-limiting step for ethanol metabolism: the oxidation of alcohol to acetaldehyde. Class 1 ADH is a homo- or heterodimeric molecule, formed by the association of 3 types of class I ADH subunits, alpha (ADH1A), beta, and gamma(ADH1C). ADH1B is also named as ADH2 and belongs to the zinc-containing alcohol dehydrogenase family. This protein can exsit as a homodimer(PMID:19365573). This antibody is specific to ADH1B.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alcohol Dehydrogenase 1B (ADH1B) Immunogen: Recombinant fusion protein corresponding to human ADH1B |
| Host | Rabbit |
| Reactivity | Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 35 kDa/39 kDa Observed MW: 40 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00325 |
| Gene ID | 125 |
| NCBI Accession | NP_000659.2 |
| Alias | ADH1B,ADH2, HEL-S-117 |
| Background | Antibody anti-ADH1B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ADH1B encodes the beta subunit of class I ADH enzymes, which are highly active in the oxidation of ethanol to acetaldehyde. This subunit is particularly important in liver and stomach tissues, where alcohol metabolism is initiated. Polymorphisms in the ADH1B gene, such as the ADH1B2 and ADH1B3 variants, are known to significantly alter enzyme activity. These variants exhibit faster ethanol oxidation rates and are associated with reduced risks of alcohol dependence and increased susceptibility to alcohol-induced flushing. ADH1B also participates in the metabolism of other alcohols and aldehydes, influencing various physiological and pathological processes. Its role in retinol metabolism connects it to pathways involved in vision and cell differentiation. Dysregulation of ADH1B activity has implications for alcohol-related liver diseases and certain cancers, particularly those of the gastrointestinal tract, where acetaldehyde accumulation is a risk factor.
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