Human Alanine--TRNA Ligase, Mitochondrial (AARS2) ELISA Kit
715€ (96 tests)
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name
Human Alanine--TRNA Ligase, Mitochondrial (AARS2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385533
tested applications
ELISA
Description
Human Alanyl-tRNA Synthetase 2, Mitochondrial (AARS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alanyl tRNA Synthetase 2, Mitochondrial (AARS2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alanine--TRNA Ligase, Mitochondrial (AARS2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5JTZ9 |
| Gene ID | 57505 |
| OMIM | 612035 |
| Alias | AARS2,AARSL,KIAA1270 |
| Background | Elisa kits for AARS2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AARS2 is an essential mitochondrial enzyme responsible for catalyzing the ligation of alanine to its corresponding tRNA (tRNA^Ala) during mitochondrial protein synthesis. This process is crucial for the translation of mitochondrial-encoded proteins, which are integral components of the oxidative phosphorylation system. Structurally, AARS2 contains a catalytic domain that ensures high specificity for alanine and tRNA^Ala, contributing to the accuracy of mitochondrial protein translation. AARS2 is predominantly expressed in energy-demanding tissues such as the brain, heart, and skeletal muscle, underscoring its role in maintaining mitochondrial function. Mutations in the AARS2 gene have been linked to mitochondrial diseases, including leukodystrophy and cardiomyopathy, which are characterized by impaired mitochondrial protein synthesis and energy production. These conditions highlight the critical importance of AARS2 in cellular energy metabolism and mitochondrial integrity. Emerging research also suggests potential links between AARS2 dysfunction and broader neurodegenerative disorders, making it a significant target for therapeutic exploration.
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