AARS2 antibody
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935106861
info@markelab.com
name
AARS2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00022
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alanyl-tRNA synthetase 2, mitochondrial (putative) (AARS2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 107 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q5JTZ9 |
| Gene ID | 57505 |
| Alias | AARS2,AARSL,KIAA1270 |
| Background | Antibody anti-AARS2 |
| Status | RUO |
| Note | Mol. Weight 107 kDa |
Descripción
AARS2 is an essential mitochondrial enzyme responsible for catalyzing the ligation of alanine to its corresponding tRNA (tRNA^Ala) during mitochondrial protein synthesis. This process is crucial for the translation of mitochondrial-encoded proteins, which are integral components of the oxidative phosphorylation system. Structurally, AARS2 contains a catalytic domain that ensures high specificity for alanine and tRNA^Ala, contributing to the accuracy of mitochondrial protein translation. AARS2 is predominantly expressed in energy-demanding tissues such as the brain, heart, and skeletal muscle, underscoring its role in maintaining mitochondrial function. Mutations in the AARS2 gene have been linked to mitochondrial diseases, including leukodystrophy and cardiomyopathy, which are characterized by impaired mitochondrial protein synthesis and energy production. These conditions highlight the critical importance of AARS2 in cellular energy metabolism and mitochondrial integrity. Emerging research also suggests potential links between AARS2 dysfunction and broader neurodegenerative disorders, making it a significant target for therapeutic exploration.
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