Human AKT Serine/Threonine Kinase 1 (AKT1) Protein (Active)

Este producto es parte de AKT1 - RAC-alpha serine/threonine-protein kinase 1
Product Graph
923€ (50 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human AKT Serine/Threonine Kinase 1 (AKT1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691590
tested applications
SDS-PAGE

Description

Human AKT1 Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human AKT1 (NP_001014431.1) (Met 1-Ala 480) was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
AKT1
Host
Insect
Origin
Human
Observed MW
Molecular Weight: 57 kDa
Sequence Fragment: Met1-Ala480
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 87% (SDS-PAGE)
Size 1
50 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile 50mM Tris, 100mM NaCl, 3mM DTT, 0.5mM PMSF, 5% Glycerol, pH 8.0.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_001014431.1
Alias
AKT1,PKB,RAC,RAC-ALPHA
Background
Protein AKT1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

The AKT (also known as Protein Kinase B) is a pivotal enzyme involved in regulating various cellular processes like metabolism, proliferation, survival, and growth. It acts downstream of phosphoinositide 3-kinase (PI3K) signaling pathway, which is activated by growth factors and cytokines. RAC-alpha serine/threonine-protein kinase is the full name of AKT. It belongs to the AGC (protein kinase A/protein kinase G/protein kinase C) family of kinases. AKT has three isoforms: AKT1, AKT2, and AKT3. Each isoform has slightly different tissue distributions and roles but shares the same basic structure and mechanism of action.Activation of AKT typically occurs through phosphorylation at two key residues: threonine 308 (Thr308) and serine 473 (Ser473). Once activated, AKT phosphorylates various downstream targets, including transcription factors, metabolic enzymes, and cell cycle regulators, ultimately leading to diverse cellular responses. Dysregulation of AKT signaling is implicated in various diseases, including cancer, diabetes, and cardiovascular diseases. Therefore, AKT has emerged as a significant target for therapeutic interventions in these conditions.

Related Products

EH0532

Human AKT1 (RAC-alpha serine/threonine-protein kinase) ELISA Kit

Ver Producto
EM1294

Mouse AKT1 (RAC-alpha serine/threonine-protein kinase) ELISA Kit

Ver Producto
ER1268

Rat AKT1 (RAC-alpha serine/threonine-protein kinase) ELISA Kit

Ver Producto