Human ADRB2 (Beta-2 adrenergic receptor) ELISA Kit

Este producto es parte de ADRB - Adrenergic receptor Beta
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935106861
info@markelab.com
name
Human ADRB2 (Beta-2 adrenergic receptor) ELISA Kit
category
ELISA Kits
provider
FineTest
reference
EH13955
tested applications
ELISA

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Human
Detection Method
Colorimetric
Assay Data
4 hours
Assay Type
Sandwich ELISA, Double Antibody
Test Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Size 1
96T
Tested Applications
ELISA
Sample Type
cell or tissue lysate, Other liquid samples
Availability
Shipped within 10-14 working days.
Storage
2-8 °C for 12 months
UniProt ID
P07550
Alias
ADRB2,ADRB2R,ADRBR,B2AR,Adrb-2,beta 2-AR,Gpcr7,BAR,ARB2
Background
Elisa kits for ADRB2
Status
RUO

The adrenergic receptor beta-2 (ADRB2) is another G-protein-coupled receptor widely distributed in smooth muscle tissues, including the lungs, blood vessels, and uterus. ADRB2 activation by catecholamines induces smooth muscle relaxation through cAMP-mediated pathways, leading to bronchodilation, vasodilation, and uterine relaxation. In the respiratory system, ADRB2 is critical for airway relaxation, making it a primary target for bronchodilators used in asthma and chronic obstructive pulmonary disease (COPD) management. Additionally, ADRB2 plays a role in glycogenolysis in the liver and skeletal muscles, promoting energy mobilization during stress or exercise. Genetic variants in ADRB2, such as Gly16Arg and Gln27Glu, influence receptor sensitivity and have been associated with differential responses to beta-agonists and susceptibility to asthma. Overactivation of ADRB2 can lead to desensitization, reducing therapeutic efficacy over time. Its involvement in multiple physiological processes underscores ADRB2's importance in both metabolic and respiratory regulation.

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