Human Adhesion Molecule With Ig Like Domain 2 (AMIGO2) Protein
1079€ (50 µg)
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name
Human Adhesion Molecule With Ig Like Domain 2 (AMIGO2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692174
tested applications
SDS-PAGE
Description
Human Adhesion Molecule With Ig Like Domain 2 (AMIGO2) Protein is a Human recombinant protein expressed in HEK293 Cells. A DNA sequence encoding the human AMIGO2 (NP_862830.1) (Met1-Thr398) was expressed with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adhesion Molecule With Ig Like Domain 2 (AMIGO2) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 42.3 kDa Observed MW: 58-63 kDa Sequence Fragment: Met1-Thr398 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% Trehalose, 5% mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized at or below -20 °C. Upon reconstitution, store between 4-7 °C for up to 7 days, or aliquot and store at or below -20 °C for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q86SJ2 |
| Gene ID | 347902 |
| NCBI Accession | NP_862830.1 |
| OMIM | 615690 |
| Alias | AMIGO2,ALI1,AMIGO-2,Alivin-1 |
| Background | Protein AMIGO2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AMIGO2, like AMIGO1, is a cell adhesion molecule that regulates cell migration, adhesion, and survival. It is expressed in various tissues, including the brain, heart, and vascular system, where it participates in developmental processes and cellular signaling. AMIGO2 plays a role in the maintenance of endothelial cell integrity and vascular remodeling, making it essential for blood vessel formation and repair. In the context of cancer, AMIGO2 is implicated in tumor angiogenesis and metastasis by promoting cell survival and migration through interactions with signaling pathways such as PI3K/AKT. Overexpression of AMIGO2 has been observed in cancers such as hepatocellular carcinoma and gastric cancer, where it contributes to tumor progression and resistance to apoptosis. AMIGO2 also supports neuronal survival under stress conditions, linking it to neuroprotection and repair mechanisms in the nervous system. Its role in both vascular biology and tumorigenesis makes AMIGO2 a potential therapeutic target.
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