Human AMPhoterin-Induced Protein 2 (AMIGO2) Protein
1118€ (50 µg)
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Name
Human AMPhoterin-Induced Protein 2 (AMIGO2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692174
Tested Applications
SDS-PAGE
Description
AMPhoterin-Induced Protein 2 (AMIGO2) protein is a recombinant Human protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | AMPhoterin-Induced Protein 2 (AMIGO2) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Thr398 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | Calculated MW: 42.3 kDa Observed MW: 58-63 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% Trehalose, 5% mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q86SJ2 |
| Gene ID | 347902 |
| NCBI Accession | NP_862830.1 |
| OMIM | 615690 |
| Alias | AMIGO2,ALI1,AMIGO-2,Alivin-1 |
| Background | Protein AMIGO2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method) Centrifuge before opening to ensure complete recovery of vial contents. |
Background
AMIGO2, like AMIGO1, is a cell adhesion molecule that regulates cell migration, adhesion, and survival. It is expressed in various tissues, including the brain, heart, and vascular system, where it participates in developmental processes and cellular signaling. AMIGO2 plays a role in the maintenance of endothelial cell integrity and vascular remodeling, making it essential for blood vessel formation and repair. In the context of cancer, AMIGO2 is implicated in tumor angiogenesis and metastasis by promoting cell survival and migration through interactions with signaling pathways such as PI3K/AKT. Overexpression of AMIGO2 has been observed in cancers such as hepatocellular carcinoma and gastric cancer, where it contributes to tumor progression and resistance to apoptosis. AMIGO2 also supports neuronal survival under stress conditions, linking it to neuroprotection and repair mechanisms in the nervous system. Its role in both vascular biology and tumorigenesis makes AMIGO2 a potential therapeutic target.
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