Human Adenylate Kinase 1 (AK1) Protein
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Description
Human AK1 Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human AK1 (AAH01116.1) (Met 1-Lys 194) was expressed, with a polyhistide tag at the N-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | AK1 |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 23.5 kDa Sequence Fragment: Met1-Lys194 Tag: N-terminal His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Supplied as sterile PBS, 10% glycerol, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | AAH01116.1 |
| Alias | HTL-S-58j |
| Background | Protein AK1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AK1 is a cytosolic enzyme that plays a critical role in cellular energy homeostasis by catalyzing the reversible transfer of a phosphate group between ADP molecules to form ATP and AMP. Highly expressed in skeletal and cardiac muscle, AK1 facilitates rapid ATP turnover, essential for high-energy-consuming tissues. AK1 mutations are associated with myopathies, hemolytic anemia, and impaired energy metabolism. Its function is critical in maintaining the ATP/ADP ratio during stress and exercise, supporting glycolysis and oxidative phosphorylation. AK1 is also involved in signaling pathways related to cellular stress responses and proliferation. Studies have shown its role in modulating metabolic responses during hypoxia.
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AK1 Antibody is a Rabbit Polyclonal antibody against AK1. Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008].
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