AK1 antibody
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Name
AK1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab00243
Tested Applications
ELISA, WB, IHC
Description
This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | adenylate kinase 1 (AK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 21 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P00568 |
| Gene ID | 203 |
| Alias | HTL-S-58j |
| Background | Antibody anti-AK1 |
| Status | RUO |
| Note | Mol. Weight 21 kDa |
Background
AK1 is a cytosolic enzyme that plays a critical role in cellular energy homeostasis by catalyzing the reversible transfer of a phosphate group between ADP molecules to form ATP and AMP. Highly expressed in skeletal and cardiac muscle, AK1 facilitates rapid ATP turnover, essential for high-energy-consuming tissues. AK1 mutations are associated with myopathies, hemolytic anemia, and impaired energy metabolism. Its function is critical in maintaining the ATP/ADP ratio during stress and exercise, supporting glycolysis and oxidative phosphorylation. AK1 is also involved in signaling pathways related to cellular stress responses and proliferation. Studies have shown its role in modulating metabolic responses during hypoxia.
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