Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ADCYAP1
proveedor
Abbexareference
abx168185Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Protein is a recombinant Human protein expressed in E. coli.
Background
Adenylate Cyclase Activating Polypeptide 1 (ADCYAP1) is a neuropeptide that acts as a ligand for its receptor, ADCYAP1 receptor. It plays crucial roles in regulating various physiological processes, including neurotransmission, neuroprotection, and modulation of the stress response. The ADCYAP1 receptor, also known as PAC1 receptor, is widely distributed throughout the central nervous system and peripheral tissues, indicating its diverse functions. Upon binding of ADCYAP1 to its receptor, intracellular signaling pathways are activated, leading to the production of cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA) and other downstream effectors. This signaling cascade influences synaptic transmission, neuronal excitability, and cellular responses to stressors. Dysregulation of ADCYAP1 signaling has been implicated in various neurological and psychiatric disorders, including anxiety, depression, and neurodegenerative diseases. Understanding the mechanisms underlying ADCYAP1 receptor activation provides insights into its physiological functions and potential therapeutic targets for neurological and psychiatric disorders. Ongoing research aims to elucidate the roles of ADCYAP1 signaling in health and disease, paving the way for the development of novel treatment strategies.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 47.2 kDa Observed MW (SDS-PAGE): 47 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile17-Leu176 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ADCYAP1
dry ice
No
availability
Shipped within 5-7 working days.
alias
PACAP
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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