Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Protein

Este producto es parte de ADCYAP1 - adenylate cyclase activating polypeptide 1 ( RECEPTOR)
Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein ADCYAP1

proveedor

Abbexa

reference

abx168185

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1) Protein is a recombinant Human protein expressed in E. coli.


Background

Adenylate Cyclase Activating Polypeptide 1 (ADCYAP1) is a neuropeptide that acts as a ligand for its receptor, ADCYAP1 receptor. It plays crucial roles in regulating various physiological processes, including neurotransmission, neuroprotection, and modulation of the stress response. The ADCYAP1 receptor, also known as PAC1 receptor, is widely distributed throughout the central nervous system and peripheral tissues, indicating its diverse functions. Upon binding of ADCYAP1 to its receptor, intracellular signaling pathways are activated, leading to the production of cyclic adenosine monophosphate (cAMP) and subsequent activation of protein kinase A (PKA) and other downstream effectors. This signaling cascade influences synaptic transmission, neuronal excitability, and cellular responses to stressors. Dysregulation of ADCYAP1 signaling has been implicated in various neurological and psychiatric disorders, including anxiety, depression, and neurodegenerative diseases. Understanding the mechanisms underlying ADCYAP1 receptor activation provides insights into its physiological functions and potential therapeutic targets for neurological and psychiatric disorders. Ongoing research aims to elucidate the roles of ADCYAP1 signaling in health and disease, paving the way for the development of novel treatment strategies.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Pituitary Adenylate Cyclase-Activating Polypeptide / PACAP (ADCYAP1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 47.2 kDa Observed MW (SDS-PAGE): 47 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile17-Leu176 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ADCYAP1


dry ice

No


availability

Shipped within 5-7 working days.


alias

PACAP


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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Tested Applications

ELISA, WB, IHC, IF/ICC, FCM

reactivity

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status

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clonality

Polyclonal

ADCYAP1 is adenylate cyclase activating polypeptide 1. Mediated by adenylate cyclase activating polypeptide 1 receptors,...

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