Human Adenosine Kinase (ADK) Protein

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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ADK
proveedor
Abbexareference
abx065151Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Adenosine Kinase (ADK) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Adenosine kinase (ADK) is a fundamental enzyme in purine metabolism that phosphorylates adenosine to produce adenosine monophosphate (AMP), thereby regulating intracellular adenosine concentrations. This activity is critical for maintaining energy balance, nucleotide synthesis, and the modulation of adenosine-dependent signaling pathways. Adenosine is a potent neuromodulator and anti-inflammatory molecule, and ADK indirectly controls its availability, affecting processes such as cellular stress responses, immune modulation, and neuronal excitability. Dysregulation of ADK has been implicated in epilepsy, ischemia, and cancer, as reduced adenosine levels exacerbate excitotoxicity, inflammation, and metabolic stress. In cancer, overexpression of ADK supports tumor metabolism by favoring nucleotide production. ADK inhibitors are under investigation as therapeutic agents for neurological disorders, where enhancing extracellular adenosine can exert protective effects against seizures and neurodegeneration. Expanding research into ADK highlights its role as a central regulator of energy metabolism and its potential as a therapeutic target for a variety of diseases.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Adenosine Kinase (ADK)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys94-Pro339 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ADK
dry ice
No
availability
Shipped within 5-12 working days.
alias
AK
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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