Family main features
Adenosine kinase (ADK) is an enzyme involved in the regulation of adenosine levels in cells by phosphorylating adenosine to produce adenosine monophosphate (AMP). Adenosine kinase plays a crucial role in the metabolism of adenosine, a nucleoside that serves as a signaling molecule in various physiological processes. By phosphorylating adenosine, ADK contributes to the regulation of adenosine levels within cells, controlling its availability for cellular signaling. ADK specifically phosphorylates adenosine at the 5' hydroxyl group, converting it into AMP. This reaction is part of the adenosine salvage pathway, which allows cells to recycle adenosine for the synthesis of ATP (adenosine triphosphate), the primary energy currency of cells. Adenosine kinase is predominantly localized in the cytoplasm of cells, although it can also be found in other cellular compartments such as the nucleus and mitochondria. Its subcellular localization may influence its role in regulating adenosine levels in different cellular compartments and its participation in specific cellular processes. Adenosine kinase is involved in various physiological processes, including the regulation of neurotransmission, modulation of synaptic activity, and control of vascular tone. Adenosine, the substrate of ADK, acts as a neuromodulator and plays roles in the central nervous system, cardiovascular system, immune system, and other tissues. Dysregulation of adenosine kinase activity or adenosine levels has been implicated in several pathological conditions, including epilepsy, neurodegenerative diseases, cancer, and cardiovascular disorders. Alterations in adenosine signaling pathways may contribute to the pathogenesis of these diseases, making ADK a potential therapeutic target.
Adenosine kinase is a monomeric enzyme with the following structural features:
Adenosine kinase does not have multiple subtypes but exists in different isoforms produced by alternative splicing:
ADK plays a significant role in various biological processes:
Adenosine kinase interacts with several molecules and pathways:
Adenosine kinase (ADK) is a critical enzyme that regulates intracellular adenosine levels by phosphorylating adenosine to adenosine monophosphate (AMP). This regulation is vital for maintaining energy metabolism, signal transduction, and various physiological processes. ADK exists in different isoforms, predominantly in the liver and brain, and interacts with pathways involved in purine metabolism and energy homeostasis. Clinically, ADK is implicated in conditions such as epilepsy, cancer, cardiovascular diseases, and inflammatory disorders. Understanding ADK's function and regulation offers potential therapeutic avenues for these conditions.
Adenosine kinase (ADK)
AK
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con ADK - Adenosine kinase
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Esta página contiene 28 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ADK | abx493586 | Human Adenosine Kinase (ADK) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.59 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ADK | abx150562 | Human Adenosine Kinase (ADK) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | < 0.57 ng/ml | 687.5 | 96 tests | RUO | |
FineTest | ADK | EM6076 | Mouse Adk (Adenosine kinase) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P55264 | RUO | ||
Abbexa | ADK | abx493587 | Mouse Adenosine Kinase (ADK) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.056 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ADK | abx153598 | Mouse Adenosine Kinase (ADK) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 618.75 | 96 tests | RUO | |
FineTest | ADK | ER6048 | Rat Adk (Adenosine kinase) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q64640 | RUO | ||
Abbexa | ADK | abx556244 | Rat Adenosine Kinase (ADK) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.161 ng/ml | 556.25 | 96 tests | Q64640 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | ADK | FNab00172 | anti- ADK antibody | human | polyclonal | Rabbit | adenosine kinase | IgG | Unconjugated | ELISA | 100µg | P55263 | RUO | |
Abbexa | ADK | abx018201 | Adenosine Kinase (ADK) Antibody | Human | Monoclonal | Mouse | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB | 300 | 100 µg | P55263 | RUO | |
Abbexa | ADK | abx101253 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P55263 | RUO | |
Abbexa | ADK | abx018200 | Adenosine Kinase (ADK) Antibody | Human | Monoclonal | Mouse | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB | 300 | 100 µg | P55263 | RUO | |
Abbexa | ADK | abx171082 | Adenosine Kinase (ADK) Antibody | Human | Monoclonal | Mouse | Adenosine Kinase (ADK) | Unconjugated | WB, IHC, IF/ICC | 787.5 | 1 ml | RUO | ||
Abbexa | ADK | abx334583 | Adenosine Kinase (ADK) Antibody (Biotin) | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Biotin | ELISA | 162.5 | 20 µg | P55263 | RUO | |
Abbexa | ADK | abx334582 | Adenosine Kinase (ADK) Antibody (FITC) | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | FITC | 162.5 | 20 µg | P55263 | RUO | ||
Abbexa | ADK | abx033170 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P55263 | RUO | |
Abbexa | ADK | abx137257 | Adenosine Kinase (ADK) Antibody | Human | Monoclonal | Mouse | Adenosine Kinase (ADK) | Unconjugated | 225 | 5 µg | RUO | |||
Abbexa | ADK | abx334581 | Adenosine Kinase (ADK) Antibody (HRP) | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | HRP | ELISA | 162.5 | 20 µg | P55263 | RUO | |
Abbexa | ADK | abx230172 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA | 350 | 100 µg | P55263 | RUO | |
Abbexa | ADK | abx328118 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB, IF/ICC | 187.5 | 50 µg | P55263 | RUO | |
Abbexa | ADK | abx214242 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB | 250 | 50 µl | P55263 | RUO | |
Abbexa | ADK | abx338791 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P55263 | RUO | |
Abbexa | ADK | abx214243 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | ELISA, WB | 250 | 50 µl | P55263 | RUO | |
Abbexa | ADK | abx119058 | Adenosine Kinase (ADK) Antibody | Human | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | WB | 43.75 | 10 µg | P55263 | RUO | |
Abbexa | ADK | abx129762 | Adenosine Kinase (ADK) Antibody | Mouse | Polyclonal | Rabbit | Adenosine Kinase (ADK) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | P55264 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ADK | abx073897 | Human Adenosine Kinase (ADK) Protein | Human | Recombinant | E. coli | SDS-PAGE | 225 | 2 µg | P55263 | RUO | |
Abbexa | ADK | abx167298 | Mouse Adenosine Kinase (ADK) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | ADK | abx065151 | Human Adenosine Kinase (ADK) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P55263 | RUO |
FineTest | ADK | P5397 | Recombinant Human ADK | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | P55263 | RUO |
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