Human Adenosine Deaminase (ADA) Protein
221€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Adenosine Deaminase (ADA) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx065150
Tested Applications
WB, SDS-PAGE
Description
Human ADA (ADA) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Adenosine Deaminase (ADA) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Lys11-Val280 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 57.2 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P00813 |
| Alias | Adenosine aminohydrolase |
| Background | Protein ADA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Adenosine deaminase (ADA) is an enzyme crucial in purine metabolism, responsible for catalyzing the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. ADA is predominantly found in lymphocytes, with high activity in tissues such as the thymus, spleen, and bone marrow. It is vital for the development and maintenance of the immune system, as its deficiency leads to the accumulation of toxic purine metabolites, which impair DNA synthesis and lymphocyte survival. Mutations in the ADA gene result in severe combined immunodeficiency (SCID), characterized by a lack of functional T, B, and NK cells. ADA is also widely studied as a marker of immune activation and inflammation in conditions like tuberculosis and rheumatoid arthritis. Therapeutic interventions for ADA deficiency include enzyme replacement therapy and gene therapy, both of which aim to restore immune function.
Productos relacionados
Adenosine Deaminase (ADA) Antibody
ADA Antibody is a Rabbit Polyclonal antibody against ADA. This gene encodes an enzyme that catalyzes the hydrolysis of a…
Ver producto
Adenosine Deaminase (ADA) Antibody
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described…
Ver producto
Adenosine Deaminase (ADA) Antibody
This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described…
Ver producto