Adenosine Deaminase (ADA) Antibody

Este producto es parte de ADA - Adenosine Deaminase
Adenosine Deaminase (ADA) Antibody

Pida mas información

935106861

info@markelab.com

Precio

175€ (20 µl)

Antibody anti-ADA

proveedor

Abbexa

reference

abx000962

Tested Applications

WB, IF/ICC

reactivity

Human, Rat

status

RUO

clonality

Polyclonal

Descripción

ADA Antibody is a Rabbit Polyclonal antibody against ADA. This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. [provided by RefSeq, Jul 2008].


Background

Adenosine deaminase (ADA) is an enzyme crucial in purine metabolism, responsible for catalyzing the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. ADA is predominantly found in lymphocytes, with high activity in tissues such as the thymus, spleen, and bone marrow. It is vital for the development and maintenance of the immune system, as its deficiency leads to the accumulation of toxic purine metabolites, which impair DNA synthesis and lymphocyte survival. Mutations in the ADA gene result in severe combined immunodeficiency (SCID), characterized by a lack of functional T, B, and NK cells. ADA is also widely studied as a marker of immune activation and inflammation in conditions like tuberculosis and rheumatoid arthritis. Therapeutic interventions for ADA deficiency include enzyme replacement therapy and gene therapy, both of which aim to restore immune function.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Rat


immunogen target

Adenosine Deaminase (ADA)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IF/ICC


purification

Purified by affinity chromatography.


buffer

PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.


size 1

20 µl


size 2

50 µl


size 3

100 µl


size 4

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

ADA


dry ice

No


availability

Shipped within 5-10 working days.


alias

Adenosine aminohydrolase


NCBI accession

NP_000013.2


note

This product is for research use only.


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