Human Adenosine Deaminase (ADA) Enzyme
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935106861
info@markelab.com
Precio
225€ (2 µg)
Protein ADA
proveedor
Abbexareference
abx073712Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Adenosine Deaminase recombinant enzyme is a recombinant recombinant enzyme produced in E. coli.
Background
Adenosine deaminase (ADA) is an enzyme crucial in purine metabolism, responsible for catalyzing the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. ADA is predominantly found in lymphocytes, with high activity in tissues such as the thymus, spleen, and bone marrow. It is vital for the development and maintenance of the immune system, as its deficiency leads to the accumulation of toxic purine metabolites, which impair DNA synthesis and lymphocyte survival. Mutations in the ADA gene result in severe combined immunodeficiency (SCID), characterized by a lack of functional T, B, and NK cells. ADA is also widely studied as a marker of immune activation and inflammation in conditions like tuberculosis and rheumatoid arthritis. Therapeutic interventions for ADA deficiency include enzyme replacement therapy and gene therapy, both of which aim to restore immune function.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Adenosine Deaminase (ADA)
host
E. coli
form
Liquid
tested applications
SDS-PAGE
size 1
2 µg
size 2
10 µg
size 3
1 mg
expression
Recombinant
purity
> 85% (SDS-PAGE)
storage
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
or code
ADA
dry ice
No
availability
Shipped within 5-10 working days.
alias
Adenosine aminohydrolase
uniprot id
note
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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