Human Adenosine Deaminase 2 (ADA2) Protein

Este producto es parte de ADA - Adenosine Deaminase
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247€ (10 µg)

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935106861
info@markelab.com
name
Human Adenosine Deaminase 2 (ADA2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167165
tested applications
WB, SDS-PAGE

Description

Human Adenosine Deaminase 2 (ADA2) Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Adenosine Deaminase 2 (ADA2)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 59.6 kDa  Observed MW (SDS-PAGE): 60 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ile30-Lys511

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NZK5
Gene ID
51816
OMIM
182410
Alias
ADGF,CECR1,IDGFL
Background
Protein ADA2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.

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