Human Adenosine Deaminase 2 (ADA2) Protein

Este producto es parte de ADA - Adenosine Deaminase
Human Adenosine Deaminase 2 (ADA2) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein ADA2

proveedor

Abbexa

reference

abx167165

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Adenosine Deaminase 2 (ADA2) Protein is a recombinant Human protein expressed in E. coli.


Background

ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Adenosine Deaminase 2 (ADA2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 59.6 kDa Observed MW (SDS-PAGE): 60 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile30-Lys511 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ADA2


dry ice

No


availability

Shipped within 5-7 working days.


alias

ADGF,CECR1,IDGFL


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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