Name: Human Adenosine Deaminase 2 (ADA2) ELISA Kit
Brand: Abbexa
SKU: abx055599
Price: 562.5 EUR
Availability: OnlineOnly

Background

ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.

Características del producto

immunogen target

Adenosine Deaminase 2 (ADA2)

reactivity

Human

test range

62.5 pg/ml - 4000 pg/ml

sensitivity

37.5 pg/ml

assay type

Sandwich

assay data

Quantitative

detection method

Colorimetric

sample type

Serum,Plasma,Other biological fluids

size 1

96 tests

alias

ADGF,CECR1,IDGFL

storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit

or code

ADA2

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q9NZK5

gene id

https://www.ncbi.nlm.nih.gov/gene/51816

note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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