Human Adenosine Deaminase 2 (ADA2) CLIA Kit
845€ (96 tests)
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Name
Human Adenosine Deaminase 2 (ADA2) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx190184
Tested Applications
CLIA
Description
Human Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | CLIA Kits |
| Immunogen Target | Adenosine Deaminase 2 (ADA2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 27.4 pg/ml - 20000 pg/ml |
| Sensitivity | < 10.1 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard: Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NZK5 |
| Gene ID | 51816 |
| OMIM | 182410 |
| Alias | ADGF,CECR1,IDGFL |
| Background | CLIA Kits ADA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
ADA2, encoded by the CECR1 gene, is a secreted protein that belongs to the adenosine deaminase family but has a distinct role compared to ADA. While ADA mainly regulates purine metabolism, ADA2 functions as a growth factor and modulates immune and vascular systems. It plays a significant role in macrophage activation, promoting M2 polarization, and regulating endothelial cell proliferation and angiogenesis. ADA2 is highly expressed in immune-related tissues, particularly monocytes and macrophages. Loss-of-function mutations in ADA2 cause Deficiency of ADA2 (DADA2), an autoinflammatory disorder characterized by systemic vasculitis, early-onset stroke, immunodeficiency, and bone marrow failure. Elevated ADA2 activity has also been linked to tumor progression and inflammation. ADA2 is a critical biomarker and therapeutic target for managing vasculitic and immune-related diseases.
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