Human Adaptor Protein Phosphotyrosine Interaction PH Domain And leucine Zipper Containing Protein 1 (APPL1) Protein

Background

APPL1 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 1) is a protein involved in several cellular processes, particularly in intracellular signaling pathways. It is a key regulator of cellular trafficking, endocytosis, and membrane receptor recycling. APPL1 contains both a pleckstrin homology (PH) domain and a leucine zipper, which are important for its interaction with phosphotyrosine residues on target proteins. These interactions are crucial for cellular communication and the regulation of various signaling pathways that control cellular homeostasis and growth. APPL1 plays a role in the regulation of insulin signaling and is involved in the formation of signaling complexes that regulate cell survival, metabolism, and proliferation. Its role in these pathways makes it an important protein in studies related to cancer, metabolic disorders, and neurodegenerative diseases.