DCC-Interacting Protein 13-Alpha (APPL1) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
DCC-Interacting Protein 13-Alpha (APPL1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx003463
Tested Applications
WB
Description
APPL1 Antibody is a Rabbit Polyclonal antibody against APPL1. The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DCC-Interacting Protein 13-Alpha (APPL1) Immunogen: Recombinant fusion protein corresponding to human APPL1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 79 kDa Observed MW: 95 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKG1 |
| Gene ID | 26060 |
| NCBI Accession | NP_036228.1 |
| Alias | APPL1, APPL, DIP13alpha, MODY14, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
| Background | Antibody anti-APPL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
APPL1 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 1) is a protein involved in several cellular processes, particularly in intracellular signaling pathways. It is a key regulator of cellular trafficking, endocytosis, and membrane receptor recycling. APPL1 contains both a pleckstrin homology (PH) domain and a leucine zipper, which are important for its interaction with phosphotyrosine residues on target proteins. These interactions are crucial for cellular communication and the regulation of various signaling pathways that control cellular homeostasis and growth. APPL1 plays a role in the regulation of insulin signaling and is involved in the formation of signaling complexes that regulate cell survival, metabolism, and proliferation. Its role in these pathways makes it an important protein in studies related to cancer, metabolic disorders, and neurodegenerative diseases.
Productos relacionados
DCC-Interacting Protein 13-Alpha (APPL1) Antibody
APPL1 Antibody is a Rabbit Polyclonal antibody against APPL1. The protein encoded by this gene has been shown to be invo…
Ver producto
DCC-Interacting Protein 13-Alpha (APPL1) Antibody
Rabbit polyclonal antibody against APPL1 protein. Immunogen region is Internal.…
Ver producto
DCC-Interacting Protein 13-Alpha (APPL1) Antibody
Rabbit Polyclonal against the APPL1 protein.…
Ver producto