Human ADAMTS10 (A disintegrin and metalloproteinase with thrombospondin motifs 10) ELISA Kit
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human ADAMTS10 (A disintegrin and metalloproteinase with thrombospondin motifs 10) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH4922
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q9H324 |
| Alias | Type 1 Motif 10,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10,WMS,WMS1,ADAMTS-10,ADAM-TS10 |
| Background | Elisa kits for ADAMTS10 |
| Status | RUO |
Background
ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10) is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS10 contains several domains, including a signal peptide, a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and multiple thrombospondin type 1 (TSP1) motifs. ADAMTS10 plays a crucial role in ECM remodeling by cleaving ECM proteins such as aggrecan, versican, and brevican. ADAMTS10 is implicated in embryonic development, particularly in skeletal development. It is involved in processes such as chondrogenesis and osteogenesis , where it regulates ECM composition and structure. Mutations in the ADAMTS10 gene have been associated with human genetic disorders such as Weill-Marchesani syndrome (WMS) and geleophysic dysplasia (GD). These disorders are characterized by skeletal abnormalities, short stature, and other connective tissue abnormalities. ADAMTS10 gene mutations can also cause GD, another rare connective tissue disorder characterized by short stature, joint contractures, and cardiac abnormalities. Like in WMS, mutations in ADAMTS10 disrupt normal ECM remodeling and tissue development, leading to the characteristic features of GD.ADAMTS10 expression levels have been found to be dysregulated in various cancers, including breast cancer, colon cancer, and gastric cancer. Its roles in ECM remodeling and tissue development suggest potential contributions to tumor progression, invasion, and metastasis
Productos relacionados
A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10) Antibody
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of…
Ver producto
A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10) Antibody
ADAMTS10 Antibody is a Rabbit Polyclonal against ADAMTS10.…
Ver producto
Human A Disintegrin And Metalloproteinase With Thrombospondin 10 (ADAMTS10) Protein
Human ADAMTS10 Protein is a recombinant Human protein expressed in E. coli.…
Ver producto